The Good Friday Appeal has officially launched, with North Melbourne securing the iconic game for its second year.

Gathered at the Royal Children's Hospital, North's Managing Director & CEO Carl Dilena, senior coach Brad Scott, along with St Kilda's CEO Matt Finnis and Coach Alan Richardson demonstrated the power of unity to raise awareness and encourage donations for the Appeal.

But it was the face of the appeal, four-year-old Arielle, who stole the show at Monday's launch while her story was shared.

North will take on the Saints in the Kick for The Kids match on Friday, March 30, with $5 from every ticket sold going directly to the Appeal.

In the lead-up to the game, the club will be supporting the Appeal with various initiatives and activities.