Stopping Nasiah Wanganeen-Milera will be among North Melbourne's top priorities as the Kangaroos return to Marvel Stadium on Sunday afternoon.
The explosive Saint was the match-winner in St Kilda's record comeback win over Melbourne last weekend.
The Kangaroos could be bolstered by some returning senior stars, and will be focused on bouncing back fast after a 101-point defeat to Geelong in Round 20.
Round 21, St Kilda v North Melbourne
Where: Marvel Stadium, Melbourne, VIC
When: Sunday, August 3 at 1.40pm AEST
How to watch: Foxtel, Kayo Sports
The opposition
Having pushed Geelong hard the previous weekend, the 14th-placed Saints underlined in Round 20 that they don't know when they are beaten.
The Saints trailed by 46 points at three-quarter time against Melbourne at Marvel Stadium. It was a margin that had never previously been overhauled in the last quarter, but Ross Lyon's men wrote history, coming from the clouds to defeat the Demons by six points.
Nasiah Wanganeen-Milera was the hero, shrugging off the attentions of two Demon defenders to take a screamer with less than a minute left on the clock to level the scores, then kicking the winner after the siren.
Dynamo Max Hall (19 disposals, six clearances) was among the Saints' best, along with the experienced Jack Sinclair.
What the coach has said
North Melbourne senior coach Alastair Clarkson on Thursday: "The spirit of the group is strong. We know we were well below our best, and we played a pretty polished outfit last week. We don't want to take any credit away from them at all but we just made simple mistakes with the footy. Kicking errors, handball errors, marking errors that just gave them the ball."
On Wanganeen-Milera: "He was always a very good player but his last six or eight weeks since he (moved) into the midfield, my goodness. He's a special player and we'll look at what we do (to counter him)."
Last time we met
Six goals either side of quarter-time set St Kilda on track for a 38-point win at Marvel Stadium in Round 8 last season.
The Roos started well, kicking three straight goals in the first quarter to carve out an early lead, but the Saints soon wrested control against the young Kangas.
Sinclair (two goals, 33 touches), Marcus Windhager (25 touches) and the dangerous Wanganeen-Milera were among the Saints' match-winners.
Young guns George Wardlaw, Colby McKercher and Harry Sheezel led the way for the Kangaroos, while Tristan Xerri was influential in the ruck, winning 40 hitouts.